The inductive capacity of oral mesenchyme and its role in tooth development (1969-1970), by Edward J. Kollar and Grace R. Baird

Tissue interactions in embryonic mouse tooth germs. II. The inductive role of the dental papilla.

SUMMARY The response of embryonic mouse dental epithelium and mesoderm to tissues of ectopic origin was examined. Isolated molar or incisor mesoderm was confronted with epithelium isolated from the plantar surface of the embryonic mouse foot plate or from the snout. Harmoniously structured teeth were formed from the foot epithelium and incisor or molar mesoderm. These data are interpreted as an...

The murine first molar tooth develops through a series of morphologically distinct stages as a result of epithelial-mes- enchymal interactions during days E9 to E18 of gestation

The murine first molar tooth develops through a series of morphologically distinct stages as a result of epithelial-mesenchymal interactions during days E9 to E18 of gestation (for review see: Thesleff et al., 1989). These events are characterized by, and are probably regulated by, changes in the extracellular matrix (Thesleff et al., 1979, 1987), production of peptide growth factors and their ...

Tissue interactions in embryonic mouse tooth germs. I. Reorganization of the dental epithelium during tooth-germ reconstruction.

The influence of the dental papilla on the development of tooth shape in embryonic mouse tooth germs.

Studies of epithelio-mesenchymal interactions during embryonic organogenesis have led to a number of conclusions regarding the nature of cellular and tissue differentiation (McLoughlin, 1963; Grobstein, 1967). For example, the importance of both the epithelium and the mesenchyme and the dependence of some systems on a limited number of specific mesenchymal tissues have been pointed out (Hilfer,...

Msx1 controls inductive signaling in mammalian tooth morphogenesis.

Members of the Msx homeobox family are thought to play important roles in inductive tissue interactions during vertebrate organogenesis, but their precise developmental function has been unclear. Mice deficient for Msx1 exhibit defects in craniofacial development and a failure of tooth morphogenesis, with an arrest in molar tooth development at the E13.5 bud stage. Because of its potential for ...